The management of patients with renal impairment is a challenge. Renal toxicity may be greater in patients with underlying renal impairment. Ibandronate sodium solution for injection drug information. Zoledronic acid treatment increased the relative risk rr and the incidence rate ir of renal impairment by 1. All bisphosphonates have known doseand infusion ratedependent effects on renal function table 3. Do not administer to patients with severe renal impairment creatinine clearance less than 30 mlminute see warnings and precautions 5. Adequately supplement patients with calcium and vitamin d 5.
Ibandronate is approved for the prevention and treatment of osteoporosis in postmenopausal women. For oral use, the recommended dose is 150 mg, taken once a month in the morning. Boniva is the brand name of the medicine ibandronate, which is used to prevent and treat osteoporosis a condition in which bones become weak and. A study of bonviva ibandronate and alendronate on renal. Such patients frequently have multiple system involvement. No dose adjustment is necessary for patients with mild or moderate renal impairment creatinine clearance greater than or equal to 30 mlmin see clinical pharmacology 12. Accp journals american college of clinical pharmacology. Pediatric drugs analgesics antihypertensive and cardiovascular agents antimicrobial agents miscellaneous agents sedatives, hypnotics, and other drugs used in psychiatry.
Your doctor will tell you to take supplements of calcium and vitamin d while you are being treated with ibandronate injection. When clinically indicated, retreat patients at the dose of initial therapy. Risk of renal impairment after treatment with ibandronate. Ibandronate is a bisphosphonate bis fos fo nayt medicine that alters bone formation and breakdown in the body. Find medication information including related drug classes, side effects, patient statistics and answers to frequently asked questions. Ibandronate is a bisphosphonate prescribed to prevent or treat osteoporosis in women after menopause. Phase ii, openlabel studies show that intensive ibandronate dosing does not compromise renal safety in patients with metastatic bone pain from a variety of tumor types. Ibandronate boniva for treatment and prevention of.
Ibandronate reduces the incidence of spine fractures. The 3mg dose is administered as a 15 to 30second intravenous injection and will provide an alternative treatment for patients who have. Further information always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. A study of bonviva ibandronate and alendronate on renal function in postmenopausal women with osteoporosis at high risk for renal disease. Adult drugs analgesics antihypertensive and cardiovascular agents antimicrobial agents miscellaneous agents sedatives, hypnotics, and other drugs used in.
For women with difficulty swallowing tablets, there is an injectable form of ibandronate that is given by iv once every three months. Ibandronate sodium solution for injection drug summary. Seyffarts directory of drug dosage in kidney disease. Renal clearance of ibandronate in patients with various degrees of renal impairment is linearly related to creatinine clearance clcr. Substitutes and alternatives to boniva ibandronate for uses like osteoporosis, cancer metastasized to the bones and high calcium from cancer. Its use is not recommended in patients with crcl ibandronate is an oral prescription medication used for treating osteoporosis in women after menopause. The auc for grade 3 renal insufficiency increased by. Data sources include ibm watson micromedex updated 4 may 2020, cerner multum updated 4 may. Dosing guidelines book school of medicine university of louisville. Effects of intravenous ibandronate injection on renal. For treatment, it is also available as an intravenous iv injection of 3 mg given every three months. Once per month dosing has similar clinical effects when compared to the previously available 2. In a twoyear, randomized trial comparing onceweekly 70 mg and daily alendronate 10 mg, the regimens were similar for increasing bmd and had similar low rates of side effects 66. Medication dosing and renal insufficiency in a pediatric cardiac intensive care unit.
Weekly dosing weekly administration of alendronate is as effective as daily dosing. Ibandronate injection is usually given once every 3 months. Boniva tablets ibandronate sodium dose, indications. Renal clearance of ibandronic acid in patients with various degrees of renal impairment is linearly.
The daily dosage has been shown to decrease vertebral fractures in women with osteoporosis and a history of previous vertebral. This chapter is dedicated to the dosing of medications in patients with chronic kidney. If necessary, your healthcare provider may recommend retreatment with the drug after monitoring your disease for two months after stopping it. Do not administer boniva injection to patients with severe renal. Renal function renal disease the designed for intravenous iv ibandronate renal safety evaluation divine study was a 1year prospective, randomized, open label, multicenter study that evaluated the renal safety of quarterly every 3 months ibandronate iv injection given over1530 s compared with infusion given over15 min, and weekly. Bisphosphonates specifically act on bone cells osteoclasts to inhibit bone resorption and turnover activity and reduce progressive bone loss and risk for fracture. Ibandronate injection comes as a solution liquid to be injected into a vein by a doctor or nurse in a medical office or clinic. Public users are able to search the site and view the abstracts for each book.
Actonel risedronate dosing, indications, interactions. Seyffarts directory of drug dosage in kidney disease authors. This book consists of a brief introductory chapter con taining a discussion of drug ther apy in patients with renal. Usual adult dose for osteolytic bone lesions of multiple myeloma. Drug dosing in chronic kidney disease family practice notebook. Selected from data included with permission and ed by first databank, inc. See full prescribing information for boniva tablets. This can slow bone loss and may help prevent bone fractures ibandronate is used to treat or prevent osteoporosis in women after menopause ibandronate may also be used for purposes not listed in this medication guide. The information on dosage adjustments in renal impairment given in this book is based on cockcroftgault creatinine clearance and not egfr, since the majority. This ed material has been downloaded from a licensed data provider and is not for distribution, except. Ibandronate teva european drugs reference encyclopedia. Boniva ibandronate dosing, indications, interactions. Bone is a living tissue constantly being remodeled. Bisphosphonates for osteoporosis in patients with renal.
Do not administer ibandronate injection to patients with severe renal impairment creatinine clearance. Treatment with intravenous bisphosphonates has been associated with renal toxicity manifested as deterioration in renal function and acute renal failure. Drug dosing in chronic kidney disease oxford medicine. Specific pharmacologic considerations in the setting of renal insufficiency. Ibandronate can be taken monthly for the treatment or prevention of osteoporosis. Compared with ibandronate, the zoledronic acid group had a significantly better baseline renal function and fewer patients had a history of renal disease. Boniva ibandronate side effects, dosage, interactions. The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Supplement with calcium and vitamin d if dietary intake is inadequate. Longterm 4year renal safety of ibandronate was demonstrated in a 2year extension of the trial. Boniva ibandronate oralinjection uses, side effects. Read the medication guide and, if available, the patient information leaflet before starting this medication and. For both prevention and treatment, ibandronate is taken once monthly as a 150 mg tablet.
Ibandronate is a bisphosphonate that can be taken daily or monthly. Renal function should be assessed before initiating therapy for osteoporosis since a patients renal function status can help guide therapeutic decisions. The renal drug handbook the st georges hospital, adult critical. Dosing, drug interactions, and pregnancy and breastfeeding information are included in the information. Dosing guidelines book school of medicine university of. Started in 1995, this collection now contains 6769 interlinked topic pages divided into a tree of 31 specialty books and 732 chapters. Bisphosphonate nephrotoxicity risks and use in ckd patients.
1325 262 1212 973 109 768 441 546 1157 583 1222 802 680 160 1362 701 177 1395 440 951 863 372 20 430 1201 946 116 1126 1449 89 225 252 817 911 253 525 1394 973 111 914 189